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A passenger jet has reportedly crashed in eastern Ukraine in an area where separatist rebels have been engaging Ukrainian military forces in recent weeks.

The Ukrainian official Anton Gerashchenko said 280 passengers and 15 crew were on board.

The Malaysia Airlines plane, travelling from Amsterdam to Kuala Lumpur, apparently crashed near the town of Snizhe, according to a report from Interfax news agency which could not immediately be confirmed. Other reports suggested it had crashed close to the nearby town of Torez.

Malaysia Airlines said via its Twitter feed: "Malaysia Airlines has lost contact of MH17 from Amsterdam. The last known position was over Ukrainian airspace. More details to follow."

A source in the Russian aviation industry told Reuters that the plane did not enter Russian airspace when expected and had crashed in eastern Ukraine.

Gerashchenko, an adviser to Ukraine's interior minister, wrote on his Facebook page that the plane had crashed in Ukrainian territory after being hit by a missile fired from a Buk launcher. Associated Press said one of its journalists had seen a similar launcher near the town of Snizhne earlier on Thursday.

In recent days the Ukrainian air force has lost planes in the area after they have been shot down by rebels. Earlier on Thursday, Ukraine accused Russia of downing one of its fighter jets inside Ukrainian territory.

Sources among the self-declared Donetsk People's Republic said they were not linked to the downing of the plane and suspected Ukrainian forces of being involved, according to comments carried by Russian news agencies.

The report of the crash comes four months after Malaysia Airlines flight MH370 vanished on a flight from Kuala Lumpur to Beijing with 239 people on board, two-thirds of them Chinese citizens. It has yet to be found despite a massive international search, which is still ongoing, but Malaysia Airlines has said it believes everyone on board died when the plane crashed into the southern Indian Ocean.

The cause of MH370's disappearance remains a mystery, with investigators suggesting the plane was deliberately diverted from its course, but there was no way of knowing whether the pilots were responding to an emergency or whether there was malicious intent.

That aircraft was a Boeing-777 – the same kind of plane as flight MH17.